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Access to an Exchange Mailbox

When using Exchange, the QM domain user must also have rights to access the mailbox specified by the MapiEmailID registry value. This permits the Quarantine Manager to use the mailbox associated with the QM domain user account to send e‑mails released from quarantine on to their intended recipients. In order that released e‑mails appear (to the recipients) to have come directly from the original sender, you must grant the ‘Send As’ Exchange permission to the QM domain user.

Important! If the QM domain user does not have the ‘Send As’ permission for a particular user, the Quarantine Manager will be unable to forward that user’s e‑mails when they are released from quarantine!

More information:

Quarantine Manager Registry Values